#122723 Epigenomics Research Associate

DESCRIPTION

The mission of the Center for Epigenomics at UC San Diego is to develop a quantitative and molecular framework to study the function and regulation of the human genome, with the ultimate goal to understand the molecular basis of cancer and other human diseases. Epigenomics is at the forefront of Precision Medicine. The epigenome, a term referring to the state of DNA methylation and the covalent modifications of histone proteins in a cell, plays a central role in regulating the functional output of the genome during development. Changes in the epigenome that result from exposure to stress, pathogenic conditions, and during aging can determine the patterns of gene expression and predispose an individual to diseases. Epigenome research promises to significantly improve our understanding of the factors that drive human development and disease. The UCSD Center for Epigenomics will work with researchers on the UCSD campus and beyond to foster the application of epigenomic concepts and technologies to clinical, translational, and basic research.

Under the direction of the Center's Associate Director, the Epigenomics Research Associate will perform experiments to map cells’ epigenomes such as ATAC-seq, ChIP-seq, CUT&RUN, single-cell ATAC-seq, single-cell RNA-seq, and Paired-Tag. The incumbent will play a key role in producing high-quality data for multiple research efforts across campus and as part of international research consortia. The incumbent will also contribute to technology development by helping to automate these workflows on liquid handling robots to maximize throughput and minimize cost per sample. The incumbent will participate in experimental design and be responsible for careful record keeping, operating laboratory equipment, troubleshooting, quality control, and periodically summarizing results for supervisors.

Additional duties may include contributing to laboratory management, organization of laboratory reagents, and maintenance of laboratory equipment. Incumbent will learn cutting-edge genomic techniques and working in a dynamic "start-up" atmosphere similar to what might be found in the biotechnology sector, yet within a vibrant academic research university. Performs other duties as assigned.

MINIMUM QUALIFICATIONS

• Theoretical knowledge in molecular biology and biological research or related field as typically attained by a bachelor’s degree and/or an equivalent combination of education and experience.

• Demonstrated ability to perform molecular biology techniques such as PCR, DNA preparation/extraction, and gel electrophoresis.

• Experience with the operation of a personal computer and software application, such as MS Word and Excel. Experience in a UNIX command environment is a plus, but not required.

• Demonstrated ability to read, comprehend, and discuss research materials.

• Excellent organizational skills and attention to detail.

• Ability to maintain effective working relationships in a diverse laboratory environment.

• Ability to communicate effectively with clinical staff, research staff, and function as a member of a research team.

• Enthusiasm for learning new techniques, and working in a fast-paced "startup" atmosphere.

• Experience with general lab maintenance including cleaning, stocking supplies.

• Demonstrated ability to follow step based experimental protocols.

• Demonstrated ability to follow established Safety and Biohazardous Material Guidelines.

PREFERRED QUALIFICATINS

• Bachelor’s degree in a relevant field.
• Hands-on experience with epigenomic assays such as ChIP-seq, RNA-seq, or ATAC-seq.
• Hands-on experience with high end laboratory equipment such as robotic platforms, cell sorters, or DNA sequencers.

SPECIAL CONDITIONS

• Occasional evenings and/or weekends may be required.
• Willingness to work with animals, lentivirus, radioactive material, human tissue and standard hazardous laboratory compounds.
• Employment is subject to a criminal background.

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html

UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening.