Job description

Job Description:
We are seeking a talented and highly motivated synthetic organic scientist to join our Discovery Chemistry team to advance cutting-edge protein degradation programs. This individual will be responsible for planning, designing and executing multi-step synthesis including compound purification and characterization. The successful candidate must have in-depth knowledge of modern synthetic chemistry principle. The candidate will work collaboratively with peers across multiple disciplines to establish and influence project strategy, and to provide scientific insight into the project milestone transition.

Responsibility

• Lead the project chemistry efforts to develop efficient chemistry for SAR study, and optimize the synthetic route to scale up lead compounds for efficacy/ tolerability study
• Actively analyze the potency, ADME/PK, pharmacology etc. data, identify the potential issues and provide scientific input to the project team
• Help team track and maintain the project files including CRO chemistry report, HiBit degradation assay data, PK data etc
• Maintain lab instruments including LC-MS, HPLC, ISCO, lyophilizer, genevac evaporator, microwave reactor etc. according to regulatory requirements
• Work closely with our computation/modeling team to use structure based design to drive SAR, become an expert on current modeling techniques
• Manage external chemistry efforts at contract research organizations (CROs)
• Contribute to the writing of patents, scientific presentations, and publications
• Survey the literature, seminars, and scientific meetings for novel methodologies to drive our projects forward
• Establish and maintain good working relationships with company colleagues

Requirements/Qualification:

• PhD in Organic Chemistry with 0-2 years of synthetic organic/medicinal chemistry experience in pharmaceutical or biotech industry or MS in Organic Chemistry with >5 years of synthetic organic/medicinal chemistry experience in pharmaceutical or biotech industry OR a BS and 5+ years of experience
• Highly productive in lab and can handle multiple projects simultaneously in a fast-paced work environment
• Excellent synthetic chemistry problem-solving capability and a track record of providing innovative solution to difficult synthesis
• Extensive experience with modern compound purification and characterization techniques (NMR, HPLC, LC-MS etc)
• Excellent oral and written communication skills, and the ability to present results at project team meetings

Job Type: Full-time

Pay: $85,000.00 - $115,000.00 per hour

Schedule:

• 8 hour shift
• Monday to Friday

Work Location: One location

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