Job description
For Current Gilead Employees and Contractors:
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Job Description
We are seeking a highly motivated and creative Scientific Director to join the Discovery Sciences and Technologies (DST) Department and lead our biophysics and biochemistry capabilities to enable the identification and nomination drug candidates across all therapeutic areas at Gilead.
DST Department members are responsible for the design and execution of rigorous, quantitative, and physiologically-relevant
in vitro biochemical and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate.
The successful candidate will be an integral member of the DST senior leadership team and work closely with various Research functions such as medicinal chemistry, structural biology and protein therapeutics across all therapeutic areas to advance transformational therapies into clinical development for patients. Gilead is a highly matrixed organization and the ability to work effectively across diverse stakeholders and therapeutic areas is a key attribute for this role.
Specific Responsibilities:
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Lead a group enzymologists, biophysicists and cellular biologists supporting small molecule and protein therapeutic drug discovery projects across all Gilead’s therapeutic areas.
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Mentor and supervise scientists and associates; providing scientific direction and guidance.
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Apply diverse methods and approaches (e.g. SPR, ITC, Mass Spec, microscopy, quantitative cellular and biochemical assays) to elucidate mechanisms of inhibitor action on target proteins and cellular signaling pathways.
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Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels.
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Ensure data quality and scientific rigor in HTS, compound profiling and mechanistic studies.
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Critically evaluate external technologies and innovations to support in-licensing and partnering efforts as well as internal development of new technologies and platforms to remain current and cutting edge for biologics and small molecule drug discovery.
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Ensure efficient use of resources to address all aspects of compound characterization.
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Manage several projects at any given time, work successfully in a cross-functional team environment and communicate clearly both verbally and in writing to a variety of audiences.
Minimum Qualifications:
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15+ years’ experience in a drug discovery environment with a PhD in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies.
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Strong background in classical enzymology and biophysics (SPR ITC, MST), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism.
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Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics.
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Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous.
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Strong analytical skills and a solid understanding of rate equations and data fitting statistics.
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The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to solve research problems using in vitro assays, including assay optimization, and troubleshooting. Must be detail orientated and organized.
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Experience in supervising direct reports at all levels including senior-level scientists. Effective group leadership skills are essential and enabling cross-functional collaboration and empowering people and developing and mentoring talent.
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Strong interpersonal and communication skills, with enthusiasm for leading in an environment characterized by rigorous scientific and innovative thinking.
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Excellent written, and oral organizational skills.
For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact
Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
careers@gilead.com
for assistance.
Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
For more information about equal employment opportunity protections, please view the
'EEO is the Law'
poster.
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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.
Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.
For Current Gilead Employees and Contractors:
Please log onto your
Internal Career Site
to apply for this job.
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